STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GRIN1Lig_chan-Glu_bd domain-containing protein. (226 aa)    
Predicted Functional Partners:
GRIN2A
Glutamate ionotropic receptor NMDA type subunit 2A.
   
0.997
GRIN2C
Glutamate ionotropic receptor NMDA type subunit 2C.
   
0.995
GRIN2B
Glutamate ionotropic receptor NMDA type subunit 2B.
   
0.980
W5PQ41_SHEEP
PBPe domain-containing protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
 
 
 0.968
CALML4
Calmodulin like 4.
   
 0.946
CALML5
Calmodulin like 5.
   
 0.940
CALM3
Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).
   
 0.940
LOC105614854
Uncharacterized protein; Belongs to the calmodulin family.
   
 0.940
NOS1
Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity); Belongs to the NOS family.
    
 0.931
P2RX4
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
   
 
 0.918
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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