NLRP2 protein (Ovis aries) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

NLRP2

NLR family pyrin domain containing 2. (1072 aa)

Predicted Functional Partners:

PADI6

0.840

TLE6

0.822

ZNF784

0.734

OOEP

0.730

NLRC4

0.722

NLRP1

0.600

KDM1B

0.589

DLGAP2

0.582

GSDMB

0.576

IL18

0.536

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLGAP2	NLRP2	ENSOARP00000005934	ENSOARP00000002124	DLG associated protein 2.	NLR family pyrin domain containing 2.	0.582
GSDMB	IL18	ENSOARP00000013168	ENSOARP00000017389	Gasdermin B.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.607
GSDMB	NLRP1	ENSOARP00000013168	ENSOARP00000002811	Gasdermin B.	NLR family pyrin domain containing 1.	0.469
GSDMB	NLRP2	ENSOARP00000013168	ENSOARP00000002124	Gasdermin B.	NLR family pyrin domain containing 2.	0.576
IL18	GSDMB	ENSOARP00000017389	ENSOARP00000013168	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Gasdermin B.	0.607
IL18	NLRC4	ENSOARP00000017389	ENSOARP00000011412	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	NLR family CARD domain containing 4.	0.858
IL18	NLRP1	ENSOARP00000017389	ENSOARP00000002811	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	NLR family pyrin domain containing 1.	0.916
IL18	NLRP2	ENSOARP00000017389	ENSOARP00000002124	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	NLR family pyrin domain containing 2.	0.536
KDM1B	NLRP2	ENSOARP00000011302	ENSOARP00000002124	Lysine demethylase 1B.	NLR family pyrin domain containing 2.	0.589
NLRC4	IL18	ENSOARP00000011412	ENSOARP00000017389	NLR family CARD domain containing 4.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.858
NLRC4	NLRP1	ENSOARP00000011412	ENSOARP00000002811	NLR family CARD domain containing 4.	NLR family pyrin domain containing 1.	0.992
NLRC4	NLRP2	ENSOARP00000011412	ENSOARP00000002124	NLR family CARD domain containing 4.	NLR family pyrin domain containing 2.	0.722
NLRP1	GSDMB	ENSOARP00000002811	ENSOARP00000013168	NLR family pyrin domain containing 1.	Gasdermin B.	0.469
NLRP1	IL18	ENSOARP00000002811	ENSOARP00000017389	NLR family pyrin domain containing 1.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.916
NLRP1	NLRC4	ENSOARP00000002811	ENSOARP00000011412	NLR family pyrin domain containing 1.	NLR family CARD domain containing 4.	0.992
NLRP1	NLRP2	ENSOARP00000002811	ENSOARP00000002124	NLR family pyrin domain containing 1.	NLR family pyrin domain containing 2.	0.600
NLRP2	DLGAP2	ENSOARP00000002124	ENSOARP00000005934	NLR family pyrin domain containing 2.	DLG associated protein 2.	0.582
NLRP2	GSDMB	ENSOARP00000002124	ENSOARP00000013168	NLR family pyrin domain containing 2.	Gasdermin B.	0.576
NLRP2	IL18	ENSOARP00000002124	ENSOARP00000017389	NLR family pyrin domain containing 2.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.536
NLRP2	KDM1B	ENSOARP00000002124	ENSOARP00000011302	NLR family pyrin domain containing 2.	Lysine demethylase 1B.	0.589