GNLY protein (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

GNLY

Saposin B-type domain-containing protein. (146 aa)

Predicted Functional Partners:

GZMA

0.942

LOC101117107

0.938

MCP-3

0.831

PRF1

0.759

NKG7

0.757

CD4

0.736

W5NUY5_SHEEP

0.707

W5NYD4_SHEEP

0.707

W5P415_SHEEP

0.707

CPPED1

0.691

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	GNLY	ENSOARP00000006749	ENSOARP00000002143	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Saposin B-type domain-containing protein.	0.736
CD4	GZMA	ENSOARP00000006749	ENSOARP00000008554	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Granzyme A; Belongs to the peptidase S1 family.	0.773
CD4	LOC101117107	ENSOARP00000006749	ENSOARP00000008562	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.718
CD4	MCP-3	ENSOARP00000006749	ENSOARP00000004938	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Mast cell protease 3.	0.901
CD4	NKG7	ENSOARP00000006749	ENSOARP00000015838	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Natural killer cell granule protein 7.	0.410
CD4	PRF1	ENSOARP00000006749	ENSOARP00000006573	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Perforin 1.	0.443
CD4	W5NUY5_SHEEP	ENSOARP00000006749	ENSOARP00000001980	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Peptidase S1 domain-containing protein.	0.831
CD4	W5NYD4_SHEEP	ENSOARP00000006749	ENSOARP00000003182	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.919
CD4	W5P415_SHEEP	ENSOARP00000006749	ENSOARP00000005167	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.890
CPPED1	GNLY	ENSOARP00000007731	ENSOARP00000002143	Calcineurin like phosphoesterase domain containing 1.	Saposin B-type domain-containing protein.	0.691
GNLY	CD4	ENSOARP00000002143	ENSOARP00000006749	Saposin B-type domain-containing protein.	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.736
GNLY	CPPED1	ENSOARP00000002143	ENSOARP00000007731	Saposin B-type domain-containing protein.	Calcineurin like phosphoesterase domain containing 1.	0.691
GNLY	GZMA	ENSOARP00000002143	ENSOARP00000008554	Saposin B-type domain-containing protein.	Granzyme A; Belongs to the peptidase S1 family.	0.942
GNLY	LOC101117107	ENSOARP00000002143	ENSOARP00000008562	Saposin B-type domain-containing protein.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.938
GNLY	MCP-3	ENSOARP00000002143	ENSOARP00000004938	Saposin B-type domain-containing protein.	Mast cell protease 3.	0.831
GNLY	NKG7	ENSOARP00000002143	ENSOARP00000015838	Saposin B-type domain-containing protein.	Natural killer cell granule protein 7.	0.757
GNLY	PRF1	ENSOARP00000002143	ENSOARP00000006573	Saposin B-type domain-containing protein.	Perforin 1.	0.759
GNLY	W5NUY5_SHEEP	ENSOARP00000002143	ENSOARP00000001980	Saposin B-type domain-containing protein.	Peptidase S1 domain-containing protein.	0.707
GNLY	W5NYD4_SHEEP	ENSOARP00000002143	ENSOARP00000003182	Saposin B-type domain-containing protein.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.707
GNLY	W5P415_SHEEP	ENSOARP00000002143	ENSOARP00000005167	Saposin B-type domain-containing protein.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.707