STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NR3C1Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] (781 aa)    
Predicted Functional Partners:
PTGES3
Prostaglandin E synthase 3.
   
 0.965
FKBP4
Peptidylprolyl isomerase.
   
 0.964
NCOA2
Nuclear receptor coactivator.
   
 0.962
NR3C2-2
Uncharacterized protein.
 
  
 0.959
FKBP5
Peptidylprolyl isomerase.
   
 0.916
NCOA1
Nuclear receptor coactivator.
   
 0.906
NCOR1
Nuclear receptor corepressor 1.
    
 0.886
HSP90AA1
Heat shock protein alpha.
   
 0.880
HSP90AB1
Heat shock protein 90 alpha family class B member 1.
   
 0.876
PPARGC1A
PPARG coactivator 1 alpha.
   
 0.858
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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