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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHPRHSNF2 histone linker PHD RING helicase. (1698 aa)    
Predicted Functional Partners:
RAD18
RAD18 E3 ubiquitin protein ligase.
    
 0.828
PGM2
Phosphoglucomutase 2; Belongs to the phosphohexose mutase family.
   
 
  0.815
PHTF2
Putative homeodomain transcription factor 2.
    
 0.778
UBE2V2
Ubiquitin conjugating enzyme E2 V2.
    
 0.772
MYSM1
Myb like, SWIRM and MPN domains 1.
   
 0.743
TMEM189-UBE2V1
UBIQUITIN_CONJUGAT_2 domain-containing protein.
    
 0.743
NTHL1
Nth like DNA glycosylase 1.
  
 
 0.741
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
  
 0.716
ARID3B
AT-rich interaction domain 3B.
   
 0.714
FANCM
FA complementation group M.
    
 0.695
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.