STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C11orf54Chromosome 11 open reading frame 54. (315 aa)    
Predicted Functional Partners:
CEP295
Centrosomal protein 295.
      
 0.696
TBC1D22B
TBC1 domain family member 22B.
      
 0.614
CCDC82
Coiled-coil domain containing 82.
      
 0.613
MED17
Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
 
    
 0.590
HEPHL1
Hephaestin like 1; Belongs to the multicopper oxidase family.
      
 0.579
NARS1
Asparaginyl-tRNA synthetase.
      
 0.534
PDE4DIP
Phosphodiesterase 4D interacting protein.
      
 0.522
HDLBP
High density lipoprotein binding protein.
      
 0.521
LIPH
Lipase H.
      
 0.520
SGO2
Shugoshin 2.
      
 0.518
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.