NCR1 protein (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NCR1

Ig-like domain-containing protein. (308 aa)

Predicted Functional Partners:

CD247

0.958

FCER1G

0.954

CD4

0.871

KLRK1

0.860

IFNG

0.816

CD244

0.753

CD19

0.741

CD69

0.738

W5NYD4_SHEEP

0.703

IL2

0.699

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD19	CD244	ENSOARP00000001799	ENSOARP00000009673	CD19 molecule.	CD244 molecule.	0.495
CD19	CD4	ENSOARP00000001799	ENSOARP00000006749	CD19 molecule.	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.985
CD19	CD69	ENSOARP00000001799	ENSOARP00000022636	CD19 molecule.	CD69 molecule.	0.881
CD19	FCER1G	ENSOARP00000001799	ENSOARP00000010507	CD19 molecule.	Fc fragment of IgE receptor Ig.	0.412
CD19	IFNG	ENSOARP00000001799	ENSOARP00000002060	CD19 molecule.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.875
CD19	IL2	ENSOARP00000001799	ENSOARP00000000019	CD19 molecule.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	0.834
CD19	KLRK1	ENSOARP00000001799	ENSOARP00000022567	CD19 molecule.	Killer cell lectin like receptor K1.	0.592
CD19	NCR1	ENSOARP00000001799	ENSOARP00000002278	CD19 molecule.	Ig-like domain-containing protein.	0.741
CD19	W5NYD4_SHEEP	ENSOARP00000001799	ENSOARP00000003182	CD19 molecule.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.645
CD244	CD19	ENSOARP00000009673	ENSOARP00000001799	CD244 molecule.	CD19 molecule.	0.495
CD244	CD4	ENSOARP00000009673	ENSOARP00000006749	CD244 molecule.	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.556
CD244	CD69	ENSOARP00000009673	ENSOARP00000022636	CD244 molecule.	CD69 molecule.	0.492
CD244	IFNG	ENSOARP00000009673	ENSOARP00000002060	CD244 molecule.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.554
CD244	IL2	ENSOARP00000009673	ENSOARP00000000019	CD244 molecule.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	0.454
CD244	KLRK1	ENSOARP00000009673	ENSOARP00000022567	CD244 molecule.	Killer cell lectin like receptor K1.	0.609
CD244	NCR1	ENSOARP00000009673	ENSOARP00000002278	CD244 molecule.	Ig-like domain-containing protein.	0.753
CD244	W5NYD4_SHEEP	ENSOARP00000009673	ENSOARP00000003182	CD244 molecule.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.591
CD247	CD4	ENSOARP00000012956	ENSOARP00000006749	T-cell surface glycoprotein CD3 zeta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of d [...]	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.560
CD247	FCER1G	ENSOARP00000012956	ENSOARP00000010507	T-cell surface glycoprotein CD3 zeta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of d [...]	Fc fragment of IgE receptor Ig.	0.622
CD247	KLRK1	ENSOARP00000012956	ENSOARP00000022567	T-cell surface glycoprotein CD3 zeta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of d [...]	Killer cell lectin like receptor K1.	0.470