STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ETNK2Ethanolamine kinase 2. (308 aa)    
Predicted Functional Partners:
RPTOR
Regulatory associated protein of MTOR complex 1.
    
 0.902
PCYT2
Phosphate cytidylyltransferase 2, ethanolamine.
     
 0.861
MLST8
MTOR associated protein, LST8 homolog.
   
 0.804
VSTM2L
V-set and transmembrane domain containing 2 like.
      
 0.799
CYP4V2
Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family.
   
  
 0.778
PIH1D1
PIH1 domain containing 1.
      
 0.736
HSD17B11
Hydroxysteroid 17-beta dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.695
GOLT1A
Golgi transport 1A.
      
 0.690
MAPKAP1
Target of rapamycin complex 2 subunit MAPKAP1; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the [...]
    
 
 0.669
ENC1
Ectodermal-neural cortex 1.
      
 0.639
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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