close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EIF4A3Uncharacterized protein; Belongs to the DEAD box helicase family. (411 aa)    
Predicted Functional Partners:
RBM8A
RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
   
 0.996
CASC3
CASC3 exon junction complex subunit.
    
 0.987
CWC22
CWC22 spliceosome associated protein homolog.
    
 0.981
ALYREF
Aly/REF export factor.
   
 0.981
MAGOH
Mago homolog, exon junction complex subunit.
   
 0.948
MAGOHB
Mago homolog B, exon junction complex subunit.
   
 0.948
W5NUQ2_SHEEP
Uncharacterized protein.
   
 0.945
NXF1
Nuclear RNA export factor 1.
   
 0.945
PRPF8
Pre-mRNA processing factor 8.
   
 0.932
RNPS1
RNA binding protein with serine rich domain 1.
   
 0.927
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.