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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
W5NW66_SHEEPUncharacterized protein. (437 aa)    
Predicted Functional Partners:
HSP90AA1
Heat shock protein alpha.
   
 0.914
HSP90AB1
Heat shock protein 90 alpha family class B member 1.
   
 0.914
PTGES3
Prostaglandin E synthase 3.
   
 0.879
TRAP1
TNF receptor associated protein 1.
   
 0.853
TSC1
TSC complex subunit 1.
   
 0.853
HSPA4
Uncharacterized protein.
   
 0.789
W5QGF5_SHEEP
Uncharacterized protein.
   
 0.789
NR3C1
Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...]
   
 0.787
AHSA1
Activator of HSP90 ATPase activity 1.
   
 
 0.787
AHSA2P
Aha1_N domain-containing protein.
   
 
 0.787
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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