node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADIPOQ | CFD | ENSOARP00000022034 | ENSOARP00000010486 | C1q domain-containing protein. | Complement factor D; Belongs to the peptidase S1 family. | 0.736 |
ADIPOQ | IL1B | ENSOARP00000022034 | ENSOARP00000022427 | C1q domain-containing protein. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.619 |
ADIPOQ | IL6 | ENSOARP00000022034 | ENSOARP00000012891 | C1q domain-containing protein. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.798 |
ADIPOQ | LEP | ENSOARP00000022034 | ENSOARP00000002554 | C1q domain-containing protein. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.968 |
ADIPOQ | PPARG | ENSOARP00000022034 | ENSOARP00000017667 | C1q domain-containing protein. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.893 |
ADIPOQ | RETN | ENSOARP00000022034 | ENSOARP00000002425 | C1q domain-containing protein. | Uncharacterized protein. | 0.942 |
ADIPOQ | TLR4 | ENSOARP00000022034 | ENSOARP00000006210 | C1q domain-containing protein. | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.487 |
ADIPOQ | W5P0G0_SHEEP | ENSOARP00000022034 | ENSOARP00000003908 | C1q domain-containing protein. | Uncharacterized protein. | 0.769 |
ARG1 | IL13 | ENSOARP00000014964 | ENSOARP00000016026 | Arginase. | Uncharacterized protein. | 0.906 |
ARG1 | IL1B | ENSOARP00000014964 | ENSOARP00000022427 | Arginase. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.799 |
ARG1 | IL6 | ENSOARP00000014964 | ENSOARP00000012891 | Arginase. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.909 |
ARG1 | PPARG | ENSOARP00000014964 | ENSOARP00000017667 | Arginase. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.566 |
ARG1 | RETN | ENSOARP00000014964 | ENSOARP00000002425 | Arginase. | Uncharacterized protein. | 0.744 |
ARG1 | TLR4 | ENSOARP00000014964 | ENSOARP00000006210 | Arginase. | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.615 |
ARG1 | W5P0G0_SHEEP | ENSOARP00000014964 | ENSOARP00000003908 | Arginase. | Uncharacterized protein. | 0.410 |
CFD | ADIPOQ | ENSOARP00000010486 | ENSOARP00000022034 | Complement factor D; Belongs to the peptidase S1 family. | C1q domain-containing protein. | 0.736 |
CFD | LEP | ENSOARP00000010486 | ENSOARP00000002554 | Complement factor D; Belongs to the peptidase S1 family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.454 |
CFD | PPARG | ENSOARP00000010486 | ENSOARP00000017667 | Complement factor D; Belongs to the peptidase S1 family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.569 |
CFD | RETN | ENSOARP00000010486 | ENSOARP00000002425 | Complement factor D; Belongs to the peptidase S1 family. | Uncharacterized protein. | 0.633 |
IL13 | ARG1 | ENSOARP00000016026 | ENSOARP00000014964 | Uncharacterized protein. | Arginase. | 0.906 |