node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACE | AGT | ENSOARP00000013888 | ENSOARP00000003247 | Angiotensin-converting enzyme. | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | 0.993 |
ACE | AGTR1 | ENSOARP00000013888 | ENSOARP00000016502 | Angiotensin-converting enzyme. | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.916 |
ACE | AGTR2 | ENSOARP00000013888 | ENSOARP00000010536 | Angiotensin-converting enzyme. | Type-2 angiotensin II receptor; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (By similarity). | 0.802 |
ACE | ATP6AP2 | ENSOARP00000013888 | ENSOARP00000001383 | Angiotensin-converting enzyme. | ATPase H+ transporting accessory protein 2. | 0.573 |
ACE | EDN1 | ENSOARP00000013888 | ENSOARP00000015104 | Angiotensin-converting enzyme. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.691 |
ACE | NR3C2 | ENSOARP00000013888 | ENSOARP00000007628 | Angiotensin-converting enzyme. | Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity); Belongs to the nuclear hormone receptor family. NR3 subfamily. | 0.733 |
ACE | NR3C2-2 | ENSOARP00000013888 | ENSOARP00000007574 | Angiotensin-converting enzyme. | Uncharacterized protein. | 0.733 |
ACE | REN | ENSOARP00000013888 | ENSOARP00000002426 | Angiotensin-converting enzyme. | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | 0.985 |
ACE | W5PU85_SHEEP | ENSOARP00000013888 | ENSOARP00000014016 | Angiotensin-converting enzyme. | Angiotensin-converting enzyme. | 0.903 |
ACE2 | AGT | ENSOARP00000013345 | ENSOARP00000003247 | Angiotensin-converting enzyme. | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | 0.991 |
ACE2 | AGTR1 | ENSOARP00000013345 | ENSOARP00000016502 | Angiotensin-converting enzyme. | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.921 |
ACE2 | AGTR2 | ENSOARP00000013345 | ENSOARP00000010536 | Angiotensin-converting enzyme. | Type-2 angiotensin II receptor; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (By similarity). | 0.833 |
ACE2 | ATP6AP2 | ENSOARP00000013345 | ENSOARP00000001383 | Angiotensin-converting enzyme. | ATPase H+ transporting accessory protein 2. | 0.576 |
ACE2 | EDN1 | ENSOARP00000013345 | ENSOARP00000015104 | Angiotensin-converting enzyme. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.785 |
ACE2 | NR3C2 | ENSOARP00000013345 | ENSOARP00000007628 | Angiotensin-converting enzyme. | Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity); Belongs to the nuclear hormone receptor family. NR3 subfamily. | 0.776 |
ACE2 | NR3C2-2 | ENSOARP00000013345 | ENSOARP00000007574 | Angiotensin-converting enzyme. | Uncharacterized protein. | 0.776 |
ACE2 | REN | ENSOARP00000013345 | ENSOARP00000002426 | Angiotensin-converting enzyme. | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | 0.984 |
AGT | ACE | ENSOARP00000003247 | ENSOARP00000013888 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Angiotensin-converting enzyme. | 0.993 |
AGT | ACE2 | ENSOARP00000003247 | ENSOARP00000013345 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Angiotensin-converting enzyme. | 0.991 |
AGT | AGTR1 | ENSOARP00000003247 | ENSOARP00000016502 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.999 |