STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SH2B1SH2B adaptor protein 1. (617 aa)    
Predicted Functional Partners:
JAK2
Tyrosine-protein kinase.
   
 0.911
PPP1R36
Protein phosphatase 1 regulatory subunit 36.
      
 0.849
GRB2
Growth factor receptor bound protein 2.
    
 0.751
DNAJC24
DnaJ heat shock protein family (Hsp40) member C24.
      
 0.723
CBL
Cbl proto-oncogene.
    
 0.662
TARS2
Threonyl-tRNA synthetase 2, mitochondrial.
      
 0.661
INSR
Tyrosine-protein kinase receptor.
    
 0.644
DNAJC13
DnaJ heat shock protein family (Hsp40) member C13.
      
 0.636
TBPL1
TATA-box binding protein like 1.
      
 0.599
IGSF11
Immunoglobulin superfamily member 11.
      
 0.596
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.