node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADIPOQ | AGRP | ENSOARP00000022034 | ENSOARP00000003192 | C1q domain-containing protein. | Agouti related neuropeptide. | 0.485 |
ADIPOQ | GCG | ENSOARP00000022034 | ENSOARP00000006813 | C1q domain-containing protein. | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] | 0.628 |
ADIPOQ | GHRL | ENSOARP00000022034 | ENSOARP00000012362 | C1q domain-containing protein. | Uncharacterized protein. | 0.720 |
ADIPOQ | LEP | ENSOARP00000022034 | ENSOARP00000002554 | C1q domain-containing protein. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.968 |
ADIPOQ | LEPR | ENSOARP00000022034 | ENSOARP00000011154 | C1q domain-containing protein. | Uncharacterized protein. | 0.693 |
ADIPOQ | NPY | ENSOARP00000022034 | ENSOARP00000011701 | C1q domain-containing protein. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | 0.483 |
ADIPOQ | POMC | ENSOARP00000022034 | ENSOARP00000019583 | C1q domain-containing protein. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate. | 0.522 |
ADIPOQ | RETN | ENSOARP00000022034 | ENSOARP00000002425 | C1q domain-containing protein. | Uncharacterized protein. | 0.942 |
ADIPOQ | STAT3 | ENSOARP00000022034 | ENSOARP00000001576 | C1q domain-containing protein. | Signal transducer and activator of transcription. | 0.439 |
AGRP | ADIPOQ | ENSOARP00000003192 | ENSOARP00000022034 | Agouti related neuropeptide. | C1q domain-containing protein. | 0.485 |
AGRP | GCG | ENSOARP00000003192 | ENSOARP00000006813 | Agouti related neuropeptide. | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] | 0.595 |
AGRP | GHRL | ENSOARP00000003192 | ENSOARP00000012362 | Agouti related neuropeptide. | Uncharacterized protein. | 0.963 |
AGRP | LEP | ENSOARP00000003192 | ENSOARP00000002554 | Agouti related neuropeptide. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.979 |
AGRP | LEPR | ENSOARP00000003192 | ENSOARP00000011154 | Agouti related neuropeptide. | Uncharacterized protein. | 0.961 |
AGRP | NPY | ENSOARP00000003192 | ENSOARP00000011701 | Agouti related neuropeptide. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | 0.985 |
AGRP | POMC | ENSOARP00000003192 | ENSOARP00000019583 | Agouti related neuropeptide. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate. | 0.985 |
AGRP | STAT3 | ENSOARP00000003192 | ENSOARP00000001576 | Agouti related neuropeptide. | Signal transducer and activator of transcription. | 0.866 |
GCG | ADIPOQ | ENSOARP00000006813 | ENSOARP00000022034 | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] | C1q domain-containing protein. | 0.628 |
GCG | AGRP | ENSOARP00000006813 | ENSOARP00000003192 | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] | Agouti related neuropeptide. | 0.595 |
GCG | GHRL | ENSOARP00000006813 | ENSOARP00000012362 | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] | Uncharacterized protein. | 0.974 |