close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIGLEC15Sialic acid binding Ig like lectin 15. (338 aa)    
Predicted Functional Partners:
SIGLEC1
Sialic acid binding Ig like lectin 1.
    
 0.859
TYROBP
TYRO protein tyrosine kinase binding protein.
   
 0.818
CD22
CD22 molecule.
    
 0.763
LGALS8
Galectin.
    
 0.703
SIAE
Sialic acid acetylesterase.
      
 0.667
PDCD1
Programmed cell death 1.
    
 0.634
MAG
Myelin associated glycoprotein.
    
 0.614
PDCD1LG2
Programmed cell death 1 ligand 2.
     
 0.602
W5PZL9_SHEEP
Uncharacterized protein.
    
 0.569
HCST
Hematopoietic cell signal transducer.
      
 0.568
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.