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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIAPH2Diaphanous related formin 2. (980 aa)    
Predicted Functional Partners:
RHOA
RHOA.
   
 0.958
PFN4
Profilin; Belongs to the profilin family.
    
 0.936
LOC101111342
Profilin; Belongs to the profilin family.
    
 0.924
PFN1
Profilin; Belongs to the profilin family.
    
 0.924
DIAPH1
Diaphanous related formin 1.
  
  
 
0.901
CDC42
Cell division cycle 42.
   
 0.651
RHOF
Uncharacterized protein.
   
 0.624
ANLN
Anillin actin binding protein.
   
 
 0.612
W5Q4M2_SHEEP
Uncharacterized protein.
   
 0.600
RHOB
Uncharacterized protein.
   
 0.600
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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