STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RPSA40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...] (295 aa)    
Predicted Functional Partners:
FAU
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
 0.996
RPS18
Ribosomal protein S18; Belongs to the universal ribosomal protein uS13 family.
  
 0.988
RPS11
Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family.
  
 0.985
RPS3
Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.
  
 0.980
RPS5
Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family.
  
 0.975
RPS20
Ribosomal_S10 domain-containing protein.
  
 0.969
RPS21
40S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family.
   
 0.952
RPS8
40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family.
   
 0.939
RPS19
Ribosomal protein S19.
   
 0.938
RPS15
Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.
  
 0.933
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.