STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (862 aa)    
Predicted Functional Partners:
PIK3CG
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.
   
 0.999
PIK3CB
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.
   
 0.983
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
   
 0.983
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
     
 0.970
PIK3R3
Uncharacterized protein.
     
 0.958
PDPK1
3-phosphoinositide dependent protein kinase 1.
     
 0.952
LYN
Tyrosine-protein kinase.
   
 
 0.950
AKT3
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
     
 0.944
IRS2
IRS-type PTB domain-containing protein.
     
 0.941
PIK3R6
Phosphoinositide-3-kinase regulatory subunit 6.
    
0.935
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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