STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1. (717 aa)    
Predicted Functional Partners:
MAPK8
Mitogen-activated protein kinase.
   
 
 0.796
APP
Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]
   
 
 0.723
MAP2K7
Protein kinase domain-containing protein.
    
 
 0.695
MAPK10
Mitogen-activated protein kinase.
   
 
 0.692
MAPK8IP2
Mitogen-activated protein kinase 8 interacting protein 2.
  
 
 
0.670
MAPK9
Mitogen-activated protein kinase.
   
 
 0.637
GOLGA1
Golgin A1.
      
 0.613
PIRT
Phosphoinositide interacting regulator of transient receptor potential channels.
      
 0.584
LRP8
LDL receptor related protein 8.
    
 
 0.579
TSPOAP1
TSPO associated protein 1.
   
 
 0.575
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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