close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VIPAS39VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog. (500 aa)    
Predicted Functional Partners:
VPS33B
Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.
   
 
 0.942
VPS33A
Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.
   
 
 0.878
PRDM4
PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation.
      
 0.724
CCSER2
Coiled-coil serine rich protein 2.
      
 0.668
SNW1
SNW domain containing 1.
      
 0.658
DYDC1
DPY30 domain containing 1.
      
 0.654
DYDC2
DPY30 domain containing 2.
      
 0.654
VPS45
Vacuolar protein sorting 45 homolog; Belongs to the STXBP/unc-18/SEC1 family.
   
  
 0.652
VPS16
Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.
   
  
 0.640
UST
Uronyl 2-sulfotransferase.
   
  
 0.632
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.