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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLC22A18Solute carrier family 22 member 18. (549 aa)    
Predicted Functional Partners:
TSSC4
Tumor suppressing subtransferable candidate 4.
      
 0.865
W5NUM4_SHEEP
PH domain-containing protein.
   
  
 0.774
IGF2R
Insulin like growth factor 2 receptor.
      
 0.738
SNX14
Sorting nexin 14.
      
 0.694
KLHDC10
Kelch domain containing 10.
      
 0.691
KCNQ1
Ion_trans domain-containing protein; Belongs to the potassium channel family.
      
 0.664
CASD1
CAS1 domain containing 1.
   
  
 0.660
PLAGL1
PLAG1 like zinc finger 1.
    
 
 0.654
PPP1R9A
Protein phosphatase 1 regulatory subunit 9A.
      
 0.654
RCL1
RNA terminal phosphate cyclase like 1.
      
 0.653
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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