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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APOA1Apolipoprotein A1. (259 aa)    
Predicted Functional Partners:
APOB
Apolipoprotein B.
   
 0.845
APOE
Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]
   
 
 0.806
PLTP
Phospholipid transfer protein.
     
 0.790
LCAT
Lecithin-cholesterol acyltransferase.
   
 0.775
GPR18
G protein-coupled receptor 18; Belongs to the G-protein coupled receptor 1 family.
      
 0.729
APOA4
Apolipoprotein A4.
  
 
0.722
APOC2
Uncharacterized protein.
   
 
 0.660
APOA2
Apolipoprotein A2.
   
 
 0.643
LOC101102413
Uncharacterized protein; Belongs to the peptidase S1 family.
   
 
 0.606
W5P9E9_SHEEP
Uncharacterized protein.
   
 0.603
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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