EPG5 protein (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EPG5

Ectopic P-granules autophagy protein 5 homolog. (2578 aa)

Predicted Functional Partners:

TECPR2

0.868

W5PHB0_SHEEP

0.769

PLEKHM1

0.741

ATG14

0.723

ATM

0.704

PSTPIP2

0.701

FAT1

0.700

VPS39

0.630

WDR45

0.623

RILP

0.623

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG14	EPG5	ENSOARP00000022668	ENSOARP00000002771	Autophagy related 14.	Ectopic P-granules autophagy protein 5 homolog.	0.723
ATG14	PLEKHM1	ENSOARP00000022668	ENSOARP00000011322	Autophagy related 14.	Pleckstrin homology and RUN domain containing M1.	0.613
ATG14	TECPR2	ENSOARP00000022668	ENSOARP00000005033	Autophagy related 14.	Tectonin beta-propeller repeat containing 2.	0.575
ATM	EPG5	ENSOARP00000012764	ENSOARP00000002771	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ectopic P-granules autophagy protein 5 homolog.	0.704
ATM	FAT1	ENSOARP00000012764	ENSOARP00000009029	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	FAT atypical cadherin 1.	0.661
ATM	W5PHB0_SHEEP	ENSOARP00000012764	ENSOARP00000009827	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Aminotran_1_2 domain-containing protein.	0.688
EPG5	ATG14	ENSOARP00000002771	ENSOARP00000022668	Ectopic P-granules autophagy protein 5 homolog.	Autophagy related 14.	0.723
EPG5	ATM	ENSOARP00000002771	ENSOARP00000012764	Ectopic P-granules autophagy protein 5 homolog.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.704
EPG5	FAT1	ENSOARP00000002771	ENSOARP00000009029	Ectopic P-granules autophagy protein 5 homolog.	FAT atypical cadherin 1.	0.700
EPG5	PLEKHM1	ENSOARP00000002771	ENSOARP00000011322	Ectopic P-granules autophagy protein 5 homolog.	Pleckstrin homology and RUN domain containing M1.	0.741
EPG5	PSTPIP2	ENSOARP00000002771	ENSOARP00000003027	Ectopic P-granules autophagy protein 5 homolog.	Proline-serine-threonine phosphatase interacting protein 2.	0.701
EPG5	RILP	ENSOARP00000002771	ENSOARP00000014035	Ectopic P-granules autophagy protein 5 homolog.	Uncharacterized protein.	0.623
EPG5	TECPR2	ENSOARP00000002771	ENSOARP00000005033	Ectopic P-granules autophagy protein 5 homolog.	Tectonin beta-propeller repeat containing 2.	0.868
EPG5	VPS39	ENSOARP00000002771	ENSOARP00000022012	Ectopic P-granules autophagy protein 5 homolog.	VPS39 subunit of HOPS complex.	0.630
EPG5	W5PHB0_SHEEP	ENSOARP00000002771	ENSOARP00000009827	Ectopic P-granules autophagy protein 5 homolog.	Aminotran_1_2 domain-containing protein.	0.769
EPG5	WDR45	ENSOARP00000002771	ENSOARP00000011812	Ectopic P-granules autophagy protein 5 homolog.	Uncharacterized protein.	0.623
FAT1	ATM	ENSOARP00000009029	ENSOARP00000012764	FAT atypical cadherin 1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.661
FAT1	EPG5	ENSOARP00000009029	ENSOARP00000002771	FAT atypical cadherin 1.	Ectopic P-granules autophagy protein 5 homolog.	0.700
FAT1	W5PHB0_SHEEP	ENSOARP00000009029	ENSOARP00000009827	FAT atypical cadherin 1.	Aminotran_1_2 domain-containing protein.	0.716
PLEKHM1	ATG14	ENSOARP00000011322	ENSOARP00000022668	Pleckstrin homology and RUN domain containing M1.	Autophagy related 14.	0.613