NLRP1 protein (Ovis aries) - STRING interaction network

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Predicted Interactions

gene neighborhood

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textmining

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protein homology

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Score

NLRP1

NLR family pyrin domain containing 1. (1390 aa)

Predicted Functional Partners:

NLRC4

0.992

BCL2L1

0.971

PYCARD

0.962

NOD2

0.958

IL18

0.916

MEFV

0.901

LOC101117013

0.870

W5PFE8_SHEEP

0.845

GSDMD

0.830

W5PVV8_SHEEP

0.781

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2L1	NLRP1	ENSOARP00000001303	ENSOARP00000002811	Bcl-x long protein.	NLR family pyrin domain containing 1.	0.971
GSDMD	IL18	ENSOARP00000000589	ENSOARP00000017389	Gasdermin D.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.871
GSDMD	LOC101117013	ENSOARP00000000589	ENSOARP00000003263	Gasdermin D.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.979
GSDMD	MEFV	ENSOARP00000000589	ENSOARP00000001635	Gasdermin D.	MEFV innate immuity regulator, pyrin.	0.928
GSDMD	NLRC4	ENSOARP00000000589	ENSOARP00000011412	Gasdermin D.	NLR family CARD domain containing 4.	0.873
GSDMD	NLRP1	ENSOARP00000000589	ENSOARP00000002811	Gasdermin D.	NLR family pyrin domain containing 1.	0.830
GSDMD	PYCARD	ENSOARP00000000589	ENSOARP00000009563	Gasdermin D.	PYD and CARD domain containing.	0.830
GSDMD	W5PFE8_SHEEP	ENSOARP00000000589	ENSOARP00000009163	Gasdermin D.	Pyrin domain-containing protein.	0.586
IL18	GSDMD	ENSOARP00000017389	ENSOARP00000000589	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Gasdermin D.	0.871
IL18	LOC101117013	ENSOARP00000017389	ENSOARP00000003263	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.850
IL18	MEFV	ENSOARP00000017389	ENSOARP00000001635	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	MEFV innate immuity regulator, pyrin.	0.933
IL18	NLRC4	ENSOARP00000017389	ENSOARP00000011412	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	NLR family CARD domain containing 4.	0.858
IL18	NLRP1	ENSOARP00000017389	ENSOARP00000002811	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	NLR family pyrin domain containing 1.	0.916
IL18	NOD2	ENSOARP00000017389	ENSOARP00000018720	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Nucleotide binding oligomerization domain containing 2.	0.642
IL18	PYCARD	ENSOARP00000017389	ENSOARP00000009563	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	PYD and CARD domain containing.	0.987
IL18	W5PFE8_SHEEP	ENSOARP00000017389	ENSOARP00000009163	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Pyrin domain-containing protein.	0.708
LOC101117013	GSDMD	ENSOARP00000003263	ENSOARP00000000589	Uncharacterized protein; Belongs to the peptidase C14A family.	Gasdermin D.	0.979
LOC101117013	IL18	ENSOARP00000003263	ENSOARP00000017389	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.850
LOC101117013	MEFV	ENSOARP00000003263	ENSOARP00000001635	Uncharacterized protein; Belongs to the peptidase C14A family.	MEFV innate immuity regulator, pyrin.	0.735
LOC101117013	NLRC4	ENSOARP00000003263	ENSOARP00000011412	Uncharacterized protein; Belongs to the peptidase C14A family.	NLR family CARD domain containing 4.	0.916