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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DACH2Uncharacterized protein. (393 aa)    
Predicted Functional Partners:
W5P8D2_SHEEP
Ski_Sno domain-containing protein.
 
      0.899
IL1RAPL2
Interleukin 1 receptor accessory protein like 2.
   
  
 0.821
EYA2
Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.
    
 
 0.721
C1GALT1C1
Uncharacterized protein.
      
 0.608
EYA4
Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.
    
 
 0.599
ZNF280D
Uncharacterized protein.
    
 
 0.598
POF1B
POF1B actin binding protein.
      
 0.593
FARP1
FERM, ARH/RhoGEF and pleckstrin domain protein 1.
      
 0.586
XPNPEP2
X-prolyl aminopeptidase 2; Belongs to the peptidase M24B family.
      
 0.583
DIAPH2
Diaphanous related formin 2.
   
  
 0.578
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.