TRADD protein (Ovis aries) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

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[Homology]

Score

TRADD

TNFRSF1A associated via death domain. (339 aa)

Predicted Functional Partners:

RIPK1

0.999

FADD

0.999

TRAF1

0.995

TRAF2-2

0.994

CASP8

0.990

TNFRSF1A

0.990

TRAF2

0.986

TRAF5

0.977

TRAF3

0.962

MIB2

0.904

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP8	FADD	ENSOARP00000018175	ENSOARP00000019828	Caspase 8; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
CASP8	MIB2	ENSOARP00000018175	ENSOARP00000003014	Caspase 8; Belongs to the peptidase C14A family.	Mindbomb E3 ubiquitin protein ligase 2.	0.518
CASP8	RIPK1	ENSOARP00000018175	ENSOARP00000001620	Caspase 8; Belongs to the peptidase C14A family.	Receptor interacting serine/threonine kinase 1.	0.996
CASP8	TNFRSF1A	ENSOARP00000018175	ENSOARP00000022803	Caspase 8; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.728
CASP8	TRADD	ENSOARP00000018175	ENSOARP00000002885	Caspase 8; Belongs to the peptidase C14A family.	TNFRSF1A associated via death domain.	0.990
CASP8	TRAF1	ENSOARP00000018175	ENSOARP00000006024	Caspase 8; Belongs to the peptidase C14A family.	TNF receptor-associated factor.	0.958
CASP8	TRAF2	ENSOARP00000018175	ENSOARP00000001587	Caspase 8; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.802
CASP8	TRAF2-2	ENSOARP00000018175	ENSOARP00000001114	Caspase 8; Belongs to the peptidase C14A family.	MATH domain-containing protein.	0.837
CASP8	TRAF3	ENSOARP00000018175	ENSOARP00000005336	Caspase 8; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.795
CASP8	TRAF5	ENSOARP00000018175	ENSOARP00000012628	Caspase 8; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.765
FADD	CASP8	ENSOARP00000019828	ENSOARP00000018175	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Caspase 8; Belongs to the peptidase C14A family.	0.999
FADD	MIB2	ENSOARP00000019828	ENSOARP00000003014	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Mindbomb E3 ubiquitin protein ligase 2.	0.545
FADD	RIPK1	ENSOARP00000019828	ENSOARP00000001620	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Receptor interacting serine/threonine kinase 1.	0.998
FADD	TNFRSF1A	ENSOARP00000019828	ENSOARP00000022803	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Uncharacterized protein.	0.990
FADD	TRADD	ENSOARP00000019828	ENSOARP00000002885	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TNFRSF1A associated via death domain.	0.999
FADD	TRAF1	ENSOARP00000019828	ENSOARP00000006024	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TNF receptor-associated factor.	0.817
FADD	TRAF2	ENSOARP00000019828	ENSOARP00000001587	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.889
FADD	TRAF2-2	ENSOARP00000019828	ENSOARP00000001114	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	MATH domain-containing protein.	0.989
FADD	TRAF3	ENSOARP00000019828	ENSOARP00000005336	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.722
FADD	TRAF5	ENSOARP00000019828	ENSOARP00000012628	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.758