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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CLEC4EC-type lectin domain family 4 member E. (213 aa)    
Predicted Functional Partners:
FCER1G
Fc fragment of IgE receptor Ig.
   
 0.985
CLEC4D
C-type lectin domain family 4 member D.
   
 
0.979
SYK
Tyrosine-protein kinase.
   
 0.961
TNFSF13
TNF superfamily member 13; Belongs to the tumor necrosis factor family.
      
 0.678
DHPS
Uncharacterized protein.
      
 0.665
CLEC1A
C-type lectin domain family 1 member A.
   
 
 0.665
CLEC9A
C-type lectin domain containing 9A.
      
0.612
IL1B
Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.
   
  
 0.553
TYROBP
TYRO protein tyrosine kinase binding protein.
   
 0.551
ACOD1
Aconitate decarboxylase 1.
   
  
 0.539
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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