STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FBXL8F-box domain-containing protein. (378 aa)    
Predicted Functional Partners:
TMEM208
Transmembrane protein 208.
      
 0.930
CACNA2D2
Calcium voltage-gated channel auxiliary subunit alpha2delta 2.
   
  
 0.882
ARFGEF1
ADP ribosylation factor guanine nucleotide exchange factor 1.
     
 0.815
SYNCRIP
Synaptotagmin binding cytoplasmic RNA interacting protein.
      
 0.797
IFRD2
Interferon related developmental regulator 2.
     
 0.731
OSBPL9
Oxysterol-binding protein; Belongs to the OSBP family.
      
 0.661
NEDD8
NEDD8 ubiquitin like modifier.
    
 0.610
W5PEG8_SHEEP
CULLIN_2 domain-containing protein; Belongs to the cullin family.
    
 0.604
CUL1
CULLIN_2 domain-containing protein; Belongs to the cullin family.
    
 0.604
GFM2
Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
      
 0.594
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.