node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTG1 | CD44 | ENSOARP00000019868 | ENSOARP00000020204 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | CD44 molecule (Indian blood group). | 0.622 |
ACTG1 | EZR | ENSOARP00000019868 | ENSOARP00000002929 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | FERM domain-containing protein. | 0.933 |
ACTG1 | ICAM1 | ENSOARP00000019868 | ENSOARP00000016801 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Ig-like domain-containing protein. | 0.520 |
ACTG1 | MSN | ENSOARP00000019868 | ENSOARP00000005414 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Moesin. | 0.928 |
ACTG1 | PRKACA | ENSOARP00000019868 | ENSOARP00000006933 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.436 |
ACTG1 | PRKACB | ENSOARP00000019868 | ENSOARP00000014812 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.434 |
ACTG1 | RDX | ENSOARP00000019868 | ENSOARP00000014242 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Radixin. | 0.922 |
CD44 | ACTG1 | ENSOARP00000020204 | ENSOARP00000019868 | CD44 molecule (Indian blood group). | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.622 |
CD44 | EZR | ENSOARP00000020204 | ENSOARP00000002929 | CD44 molecule (Indian blood group). | FERM domain-containing protein. | 0.954 |
CD44 | ICAM1 | ENSOARP00000020204 | ENSOARP00000016801 | CD44 molecule (Indian blood group). | Ig-like domain-containing protein. | 0.925 |
CD44 | MSN | ENSOARP00000020204 | ENSOARP00000005414 | CD44 molecule (Indian blood group). | Moesin. | 0.961 |
CD44 | RDX | ENSOARP00000020204 | ENSOARP00000014242 | CD44 molecule (Indian blood group). | Radixin. | 0.963 |
CD44 | SLC9A1 | ENSOARP00000020204 | ENSOARP00000004093 | CD44 molecule (Indian blood group). | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.734 |
EZR | ACTG1 | ENSOARP00000002929 | ENSOARP00000019868 | FERM domain-containing protein. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.933 |
EZR | CD44 | ENSOARP00000002929 | ENSOARP00000020204 | FERM domain-containing protein. | CD44 molecule (Indian blood group). | 0.954 |
EZR | ICAM1 | ENSOARP00000002929 | ENSOARP00000016801 | FERM domain-containing protein. | Ig-like domain-containing protein. | 0.972 |
EZR | MSN | ENSOARP00000002929 | ENSOARP00000005414 | FERM domain-containing protein. | Moesin. | 0.991 |
EZR | PRKACA | ENSOARP00000002929 | ENSOARP00000006933 | FERM domain-containing protein. | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.962 |
EZR | PRKACB | ENSOARP00000002929 | ENSOARP00000014812 | FERM domain-containing protein. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.962 |
EZR | PRKCE | ENSOARP00000002929 | ENSOARP00000006275 | FERM domain-containing protein. | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] | 0.927 |