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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MEPEMatrix extracellular phosphoglycoprotein. (505 aa)    
Predicted Functional Partners:
SOST
Sclerostin.
      
 0.876
PHEX
Phosphate regulating endopeptidase homolog X-linked.
   
 
 0.873
DMP1
Dentin matrix acidic phosphoprotein 1.
   
  
 0.840
ENAM
Enamelin.
  
   
 0.800
FGF23
Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.
      
 0.778
NCAPG
Non-SMC condensin I complex subunit G.
      
 0.774
IBSP
Integrin binding sialoprotein.
   
  
 0.773
TMBIM4
Uncharacterized protein; Belongs to the BI1 family.
      
 0.752
ZNF23-2
Uncharacterized protein.
      
 0.743
FAM184B
Family with sequence similarity 184 member B.
      
 0.737
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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