Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RBFOX3RNA binding protein fox-1 homolog 3; RNA-binding protein that regulates alternative splicing events. (386 aa)    
Predicted Functional Partners:
RBFOX1
RRM domain-containing protein.
   
 0.963
RBFOX2
RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events.
   
 0.954
AIF1
Allograft inflammatory factor 1.
    
 
 0.761
GFAP
Glial fibrillary acidic protein; Belongs to the intermediate filament family.
   
 
 0.757
VPS37C
VPS37C subunit of ESCRT-I.
      
 0.692
POLR2H
DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
   
 
 0.687
PRDM4
PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation.
    
 
 0.680
NES
Nestin; Belongs to the intermediate filament family.
    
 0.659
DCX
Doublecortin.
      
 0.642
S100B
Protein S100; Belongs to the S-100 family.
   
  
 0.636
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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