node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKR1D1 | CYP11B1 | ENSOARP00000010776 | ENSOARP00000000890 | Aldo-keto reductase family 1 member D1. | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | 0.918 |
AKR1D1 | HSD11B1 | ENSOARP00000010776 | ENSOARP00000013948 | Aldo-keto reductase family 1 member D1. | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of corticosterone to 11- dehydrocorticosterone. | 0.920 |
AKR1D1 | HSD11B1L | ENSOARP00000010776 | ENSOARP00000008034 | Aldo-keto reductase family 1 member D1. | Hydroxysteroid 11-beta dehydrogenase 1 like. | 0.913 |
AKR1D1 | HSD11B2 | ENSOARP00000010776 | ENSOARP00000003179 | Aldo-keto reductase family 1 member D1. | Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. | 0.924 |
AKR1D1 | HSD3B1 | ENSOARP00000010776 | ENSOARP00000021913 | Aldo-keto reductase family 1 member D1. | 3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. | 0.906 |
CYP11B1 | AKR1D1 | ENSOARP00000000890 | ENSOARP00000010776 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | Aldo-keto reductase family 1 member D1. | 0.918 |
CYP11B1 | HSD11B1 | ENSOARP00000000890 | ENSOARP00000013948 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of corticosterone to 11- dehydrocorticosterone. | 0.948 |
CYP11B1 | HSD11B1L | ENSOARP00000000890 | ENSOARP00000008034 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | Hydroxysteroid 11-beta dehydrogenase 1 like. | 0.918 |
CYP11B1 | HSD11B2 | ENSOARP00000000890 | ENSOARP00000003179 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. | 0.941 |
CYP11B1 | HSD3B1 | ENSOARP00000000890 | ENSOARP00000021913 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | 3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. | 0.955 |
CYP11B1 | NR3C2 | ENSOARP00000000890 | ENSOARP00000007628 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity); Belongs to the nuclear hormone receptor family. NR3 subfamily. | 0.549 |
CYP11B1 | NR3C2-2 | ENSOARP00000000890 | ENSOARP00000007574 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | Uncharacterized protein. | 0.550 |
CYP11B1 | POMC | ENSOARP00000000890 | ENSOARP00000019583 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate. | 0.704 |
HSD11B1 | AKR1D1 | ENSOARP00000013948 | ENSOARP00000010776 | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of corticosterone to 11- dehydrocorticosterone. | Aldo-keto reductase family 1 member D1. | 0.920 |
HSD11B1 | CYP11B1 | ENSOARP00000013948 | ENSOARP00000000890 | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of corticosterone to 11- dehydrocorticosterone. | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | 0.948 |
HSD11B1 | HSD11B1L | ENSOARP00000013948 | ENSOARP00000008034 | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of corticosterone to 11- dehydrocorticosterone. | Hydroxysteroid 11-beta dehydrogenase 1 like. | 0.913 |
HSD11B1 | HSD11B2 | ENSOARP00000013948 | ENSOARP00000003179 | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of corticosterone to 11- dehydrocorticosterone. | Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. | 0.995 |
HSD11B1 | HSD3B1 | ENSOARP00000013948 | ENSOARP00000021913 | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of corticosterone to 11- dehydrocorticosterone. | 3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. | 0.910 |
HSD11B1 | NR3C1 | ENSOARP00000013948 | ENSOARP00000002152 | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of corticosterone to 11- dehydrocorticosterone. | Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] | 0.841 |
HSD11B1 | NR3C2 | ENSOARP00000013948 | ENSOARP00000007628 | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of corticosterone to 11- dehydrocorticosterone. | Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity); Belongs to the nuclear hormone receptor family. NR3 subfamily. | 0.797 |