STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LEMD3LEM domain containing 3. (856 aa)    
Predicted Functional Partners:
TMBIM4
Uncharacterized protein; Belongs to the BI1 family.
      
 0.848
ZNF23-2
Uncharacterized protein.
    
 
 0.819
SMAD1
Mothers against decapentaplegic homolog.
   
 
 0.812
MSRB3
Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.
      
 0.811
R3HDM1
R3H domain containing 1.
    
 
 0.785
CDC5L
Cell division cycle 5 like.
   
 
 0.753
BANF1
Barrier to autointegration factor 1.
   
 0.750
WIF1
WNT inhibitory factor 1.
      
 0.737
SMAD3
Mothers against decapentaplegic homolog.
   
 
 0.732
SMAD2
Mothers against decapentaplegic homolog.
   
 
 0.717
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.