W5NYP6_SHEEP protein (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

W5NYP6_SHEEP

RING-type domain-containing protein. (596 aa)

Predicted Functional Partners:

LGR4

0.817

LGR5

0.801

RSPO2

0.762

RSPO1

0.704

RSPO3

0.699

RSPO4

0.694

LRP6

0.666

LGR6

0.582

LRP5

0.572

AXIN2

0.550

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	LGR4	ENSOARP00000016613	ENSOARP00000015999	Axin 2.	Leucine rich repeat containing G protein-coupled receptor 4.	0.475
AXIN2	LGR5	ENSOARP00000016613	ENSOARP00000015619	Axin 2.	Leucine rich repeat containing G protein-coupled receptor 5.	0.806
AXIN2	LGR6	ENSOARP00000016613	ENSOARP00000019939	Axin 2.	Uncharacterized protein.	0.703
AXIN2	LRP5	ENSOARP00000016613	ENSOARP00000016476	Axin 2.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.904
AXIN2	LRP6	ENSOARP00000016613	ENSOARP00000022437	Axin 2.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.922
AXIN2	RSPO1	ENSOARP00000016613	ENSOARP00000021275	Axin 2.	R-spondin 1.	0.486
AXIN2	RSPO2	ENSOARP00000016613	ENSOARP00000016136	Axin 2.	R-spondin 2.	0.488
AXIN2	RSPO3	ENSOARP00000016613	ENSOARP00000008291	Axin 2.	R-spondin 3.	0.537
AXIN2	W5NYP6_SHEEP	ENSOARP00000016613	ENSOARP00000003294	Axin 2.	RING-type domain-containing protein.	0.550
LGR4	AXIN2	ENSOARP00000015999	ENSOARP00000016613	Leucine rich repeat containing G protein-coupled receptor 4.	Axin 2.	0.475
LGR4	LGR5	ENSOARP00000015999	ENSOARP00000015619	Leucine rich repeat containing G protein-coupled receptor 4.	Leucine rich repeat containing G protein-coupled receptor 5.	0.964
LGR4	LGR6	ENSOARP00000015999	ENSOARP00000019939	Leucine rich repeat containing G protein-coupled receptor 4.	Uncharacterized protein.	0.940
LGR4	LRP5	ENSOARP00000015999	ENSOARP00000016476	Leucine rich repeat containing G protein-coupled receptor 4.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.675
LGR4	LRP6	ENSOARP00000015999	ENSOARP00000022437	Leucine rich repeat containing G protein-coupled receptor 4.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.536
LGR4	RSPO1	ENSOARP00000015999	ENSOARP00000021275	Leucine rich repeat containing G protein-coupled receptor 4.	R-spondin 1.	0.997
LGR4	RSPO2	ENSOARP00000015999	ENSOARP00000016136	Leucine rich repeat containing G protein-coupled receptor 4.	R-spondin 2.	0.974
LGR4	RSPO3	ENSOARP00000015999	ENSOARP00000008291	Leucine rich repeat containing G protein-coupled receptor 4.	R-spondin 3.	0.992
LGR4	RSPO4	ENSOARP00000015999	ENSOARP00000020243	Leucine rich repeat containing G protein-coupled receptor 4.	R-spondin 4.	0.990
LGR4	W5NYP6_SHEEP	ENSOARP00000015999	ENSOARP00000003294	Leucine rich repeat containing G protein-coupled receptor 4.	RING-type domain-containing protein.	0.817
LGR5	AXIN2	ENSOARP00000015619	ENSOARP00000016613	Leucine rich repeat containing G protein-coupled receptor 5.	Axin 2.	0.806