node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACLY | CS | ENSOARP00000019140 | ENSOARP00000010102 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Citrate synthase; Belongs to the citrate synthase family. | 0.996 |
ACLY | FH | ENSOARP00000019140 | ENSOARP00000009376 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Fumarate hydratase. | 0.594 |
ACLY | GOT2 | ENSOARP00000019140 | ENSOARP00000001804 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Aspartate aminotransferase. | 0.872 |
ACLY | IDH1 | ENSOARP00000019140 | ENSOARP00000020383 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Isocitrate dehydrogenase [NADP] cytoplasmic. | 0.842 |
ACLY | IDH2 | ENSOARP00000019140 | ENSOARP00000012882 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.838 |
ACLY | PKLR | ENSOARP00000019140 | ENSOARP00000004524 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.486 |
ACLY | SUCLG1 | ENSOARP00000019140 | ENSOARP00000021907 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. | 0.985 |
ACLY | URB2 | ENSOARP00000019140 | ENSOARP00000003303 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | URB2 ribosome biogenesis homolog. | 0.589 |
CS | ACLY | ENSOARP00000010102 | ENSOARP00000019140 | Citrate synthase; Belongs to the citrate synthase family. | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.996 |
CS | FH | ENSOARP00000010102 | ENSOARP00000009376 | Citrate synthase; Belongs to the citrate synthase family. | Fumarate hydratase. | 0.984 |
CS | GOT2 | ENSOARP00000010102 | ENSOARP00000001804 | Citrate synthase; Belongs to the citrate synthase family. | Aspartate aminotransferase. | 0.935 |
CS | IDH1 | ENSOARP00000010102 | ENSOARP00000020383 | Citrate synthase; Belongs to the citrate synthase family. | Isocitrate dehydrogenase [NADP] cytoplasmic. | 0.971 |
CS | IDH2 | ENSOARP00000010102 | ENSOARP00000012882 | Citrate synthase; Belongs to the citrate synthase family. | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.970 |
CS | PKLR | ENSOARP00000010102 | ENSOARP00000004524 | Citrate synthase; Belongs to the citrate synthase family. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.441 |
CS | SUCLG1 | ENSOARP00000010102 | ENSOARP00000021907 | Citrate synthase; Belongs to the citrate synthase family. | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. | 0.896 |
CS | URB2 | ENSOARP00000010102 | ENSOARP00000003303 | Citrate synthase; Belongs to the citrate synthase family. | URB2 ribosome biogenesis homolog. | 0.805 |
FH | ACLY | ENSOARP00000009376 | ENSOARP00000019140 | Fumarate hydratase. | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.594 |
FH | CS | ENSOARP00000009376 | ENSOARP00000010102 | Fumarate hydratase. | Citrate synthase; Belongs to the citrate synthase family. | 0.984 |
FH | GOT2 | ENSOARP00000009376 | ENSOARP00000001804 | Fumarate hydratase. | Aspartate aminotransferase. | 0.971 |
FH | IDH1 | ENSOARP00000009376 | ENSOARP00000020383 | Fumarate hydratase. | Isocitrate dehydrogenase [NADP] cytoplasmic. | 0.866 |