W5NYY3_SHEEP protein (Ovis aries) - STRING interaction network

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Predicted Interactions

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Score

W5NYY3_SHEEP

Uncharacterized protein. (392 aa)

Predicted Functional Partners:

TP53

0.806

BEND6

0.692

SVOPL

0.686

PHF20L1

0.604

ZCWPW2

0.562

ZNF391

0.551

KMT5A

0.542

E2F4

0.530

RNF8

0.522

CBX4

0.521

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BEND6	W5NYY3_SHEEP	ENSOARP00000006289	ENSOARP00000003381	BEN domain containing 6.	Uncharacterized protein.	0.692
CBX4	W5NYY3_SHEEP	ENSOARP00000002776	ENSOARP00000003381	Chromobox 4.	Uncharacterized protein.	0.521
E2F4	TP53	ENSOARP00000002976	ENSOARP00000016707	E2F transcription factor 4.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.483
E2F4	W5NYY3_SHEEP	ENSOARP00000002976	ENSOARP00000003381	E2F transcription factor 4.	Uncharacterized protein.	0.530
KMT5A	TP53	ENSOARP00000004029	ENSOARP00000016707	Lysine methyltransferase 5A.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.810
KMT5A	W5NYY3_SHEEP	ENSOARP00000004029	ENSOARP00000003381	Lysine methyltransferase 5A.	Uncharacterized protein.	0.542
PHF20L1	W5NYY3_SHEEP	ENSOARP00000006461	ENSOARP00000003381	PHD finger protein 20 like 1.	Uncharacterized protein.	0.604
RNF8	TP53	ENSOARP00000015618	ENSOARP00000016707	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.477
RNF8	W5NYY3_SHEEP	ENSOARP00000015618	ENSOARP00000003381	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	Uncharacterized protein.	0.522
SVOPL	W5NYY3_SHEEP	ENSOARP00000011069	ENSOARP00000003381	SVOP like.	Uncharacterized protein.	0.686
TP53	E2F4	ENSOARP00000016707	ENSOARP00000002976	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	E2F transcription factor 4.	0.483
TP53	KMT5A	ENSOARP00000016707	ENSOARP00000004029	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	Lysine methyltransferase 5A.	0.810
TP53	RNF8	ENSOARP00000016707	ENSOARP00000015618	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.477
TP53	W5NYY3_SHEEP	ENSOARP00000016707	ENSOARP00000003381	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	Uncharacterized protein.	0.806
W5NYY3_SHEEP	BEND6	ENSOARP00000003381	ENSOARP00000006289	Uncharacterized protein.	BEN domain containing 6.	0.692
W5NYY3_SHEEP	CBX4	ENSOARP00000003381	ENSOARP00000002776	Uncharacterized protein.	Chromobox 4.	0.521
W5NYY3_SHEEP	E2F4	ENSOARP00000003381	ENSOARP00000002976	Uncharacterized protein.	E2F transcription factor 4.	0.530
W5NYY3_SHEEP	KMT5A	ENSOARP00000003381	ENSOARP00000004029	Uncharacterized protein.	Lysine methyltransferase 5A.	0.542
W5NYY3_SHEEP	PHF20L1	ENSOARP00000003381	ENSOARP00000006461	Uncharacterized protein.	PHD finger protein 20 like 1.	0.604
W5NYY3_SHEEP	RNF8	ENSOARP00000003381	ENSOARP00000015618	Uncharacterized protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.522