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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLCH1Phosphoinositide phospholipase C. (1696 aa)    
Predicted Functional Partners:
PIP5K1A
Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha.
   
 0.936
PIP5K1B
Phosphatidylinositol-4-phosphate 5-kinase type 1 beta.
   
 0.924
IPMK
Kinase; Belongs to the inositol phosphokinase (IPK) family.
    
 0.913
INPP5K
Inositol polyphosphate-5-phosphatase K.
     
 0.907
PTEN
Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.
    
 0.903
ISOC1
Isochorismatase domain containing 1.
      
 0.818
LIX1
Limb and CNS expressed 1.
      
 0.768
RASGEF1C
RasGEF domain family member 1C.
      
 0.747
PIP4K2A
Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha.
   
 0.736
PIP4K2C
Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma.
   
 0.736
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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