STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F8Uncharacterized protein; Belongs to the multicopper oxidase family. (2258 aa)    
Predicted Functional Partners:
VWF
Von Willebrand factor.
    
 0.893
F2
Uncharacterized protein; Belongs to the peptidase S1 family.
    
 0.877
F9
Coagulation factor IX; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
   
 0.876
F10
Coagulation factor X.
   
 0.835
PROS1
Protein S.
   
 0.757
W5NXF8_SHEEP
TIL domain-containing protein.
    
 0.751
PROC
Protein C, inactivator of coagulation factors Va and VIIIa; Belongs to the peptidase S1 family.
    
 0.744
F5
Coagulation factor V; Belongs to the multicopper oxidase family.
  
  
0.730
W5PD49_SHEEP
Uncharacterized protein.
   
 0.711
SERPINC1
Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity).
   
 0.673
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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