Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
W5NZK6_SHEEPUncharacterized protein. (440 aa)    
Predicted Functional Partners:
PLA2G3
Phospholipase A2 group III.
     
 0.922
LYPLA1
Lysophospholipase 1.
     
 0.917
PNPLA6
Patatin like phospholipase domain containing 6.
     
 0.916
PLB1
Phospholipase B1.
     
 0.915
PPARG
Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]
     
 0.908
PPARD
Peroxisome proliferator activated receptor delta.
     
 0.906
LCAT
Lecithin-cholesterol acyltransferase.
     
0.904
GPCPD1
Glycerophosphocholine phosphodiesterase 1.
     
 0.904
PLA2G12B
Phospholipase A2 group XIIB.
   
 
 0.868
PLA2G10
Phospholipase A(2).
     
 0.824
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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