STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
USP36Ubiquitin specific peptidase 36; Belongs to the peptidase C19 family. (1080 aa)    
Predicted Functional Partners:
ZNF598
Zinc finger protein 598.
   
  
 0.878
ZNF768
Zinc finger protein 768.
      
 0.834
DNMBP
Dynamin binding protein.
      
 0.829
W5PNG0_SHEEP
Uncharacterized protein.
      
 0.797
RAPGEF1
Rap guanine nucleotide exchange factor 1.
      
 0.791
RBBP6
RB binding protein 6, ubiquitin ligase.
      
 0.749
USP39
Ubiquitin specific peptidase 39.
      
0.658
RNF8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
      
 0.651
HUWE1
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.
      
 0.642
SUDS3
SDS3 homolog, SIN3A corepressor complex component.
    
 0.628
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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