node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNA2 | EME1 | ENSOARP00000005451 | ENSOARP00000004907 | DNA replication helicase/nuclease 2. | Essential meiotic structure-specific endonuclease 1. | 0.768 |
DNA2 | ERCC1 | ENSOARP00000005451 | ENSOARP00000010674 | DNA replication helicase/nuclease 2. | ERCC excision repair 1, endonuclease non-catalytic subunit. | 0.669 |
DNA2 | MUS81 | ENSOARP00000005451 | ENSOARP00000019554 | DNA replication helicase/nuclease 2. | MUS81 structure-specific endonuclease subunit. | 0.934 |
DNA2 | NARS1 | ENSOARP00000005451 | ENSOARP00000005627 | DNA replication helicase/nuclease 2. | Asparaginyl-tRNA synthetase. | 0.466 |
DNA2 | RMI1 | ENSOARP00000005451 | ENSOARP00000003733 | DNA replication helicase/nuclease 2. | RecQ mediated genome instability 1. | 0.870 |
DNA2 | RMI2 | ENSOARP00000005451 | ENSOARP00000007030 | DNA replication helicase/nuclease 2. | RecQ mediated genome instability 2. | 0.905 |
DNA2 | RTEL1 | ENSOARP00000005451 | ENSOARP00000011129 | DNA replication helicase/nuclease 2. | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] | 0.752 |
DNA2 | SLX1 | ENSOARP00000005451 | ENSOARP00000003700 | DNA replication helicase/nuclease 2. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. | 0.892 |
DNA2 | SLX4 | ENSOARP00000005451 | ENSOARP00000002172 | DNA replication helicase/nuclease 2. | SLX4 structure-specific endonuclease subunit. | 0.775 |
DNA2 | WRN | ENSOARP00000005451 | ENSOARP00000000142 | DNA replication helicase/nuclease 2. | WRN RecQ like helicase. | 0.991 |
EME1 | DNA2 | ENSOARP00000004907 | ENSOARP00000005451 | Essential meiotic structure-specific endonuclease 1. | DNA replication helicase/nuclease 2. | 0.768 |
EME1 | ERCC1 | ENSOARP00000004907 | ENSOARP00000010674 | Essential meiotic structure-specific endonuclease 1. | ERCC excision repair 1, endonuclease non-catalytic subunit. | 0.889 |
EME1 | MUS81 | ENSOARP00000004907 | ENSOARP00000019554 | Essential meiotic structure-specific endonuclease 1. | MUS81 structure-specific endonuclease subunit. | 0.999 |
EME1 | NARS1 | ENSOARP00000004907 | ENSOARP00000005627 | Essential meiotic structure-specific endonuclease 1. | Asparaginyl-tRNA synthetase. | 0.701 |
EME1 | RMI1 | ENSOARP00000004907 | ENSOARP00000003733 | Essential meiotic structure-specific endonuclease 1. | RecQ mediated genome instability 1. | 0.728 |
EME1 | RMI2 | ENSOARP00000004907 | ENSOARP00000007030 | Essential meiotic structure-specific endonuclease 1. | RecQ mediated genome instability 2. | 0.750 |
EME1 | RTEL1 | ENSOARP00000004907 | ENSOARP00000011129 | Essential meiotic structure-specific endonuclease 1. | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] | 0.551 |
EME1 | SLX1 | ENSOARP00000004907 | ENSOARP00000003700 | Essential meiotic structure-specific endonuclease 1. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. | 0.934 |
EME1 | SLX4 | ENSOARP00000004907 | ENSOARP00000002172 | Essential meiotic structure-specific endonuclease 1. | SLX4 structure-specific endonuclease subunit. | 0.947 |
EME1 | WRN | ENSOARP00000004907 | ENSOARP00000000142 | Essential meiotic structure-specific endonuclease 1. | WRN RecQ like helicase. | 0.723 |