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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WDFY3WD repeat and FYVE domain containing 3. (3522 aa)    
Predicted Functional Partners:
PLEKHG7
Chromosome 12 open reading frame 74.
    
 0.870
ATG5
Autophagy protein 5; Involved in autophagic vesicle formation.
    
 0.850
AUTS2
Uncharacterized protein.
      
 0.836
ATG12
Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.
    
 0.805
FER1L6
Fer-1 like family member 6.
      
 0.726
SQSTM1
Uncharacterized protein.
   
 
 0.704
WDFY2
WD repeat and FYVE domain containing 2.
      
0.696
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 
 0.682
TBC1D19
TBC1 domain family member 19.
      
 0.663
RIMS2
Regulating synaptic membrane exocytosis 2.
      
 0.658
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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