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The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EFCAB10EF-hand calcium binding domain 10. (146 aa)    
Predicted Functional Partners:
C16orf78
Chromosome 16 open reading frame 78.
   
  
 0.592
STPG2
Sperm tail PG-rich repeat containing 2.
      
 0.575
DEFB125
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.553
CFAP206
Uncharacterized protein.
   
  
 0.547
TP53I11
Tumor protein p53 inducible protein 11.
      
 0.535
CALCA-2
Calcitonin gene-related peptide; CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role; Belongs to the calcitonin family.
      
 0.532
PRODH2
Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.
      
 0.527
FBXW12
WD_REPEATS_REGION domain-containing protein.
      
 0.518
CDK20
Cyclin dependent kinase 20; Belongs to the protein kinase superfamily.
      
 0.518
W5NPW0_SHEEP
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.500
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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