STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LYSTLysosomal trafficking regulator. (3847 aa)    
Predicted Functional Partners:
HPS5
Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
   
  
 0.775
TYR
Uncharacterized protein.
    
 
 0.712
ARMH3
Armadillo like helical domain containing 3.
      
 0.595
WIPF3
WAS/WASL interacting protein family member 3.
    
 
 0.592
BLOC1S2
Biogenesis of lysosomal organelles complex 1 subunit 2.
      
 0.586
ALPK1
Alpha kinase 1.
      
 0.581
HPS6
HPS6 biogenesis of lysosomal organelles complex 2 subunit 3.
      
 0.579
TMEM132C
Transmembrane protein 132C.
   
 
 0.578
W5NUX1_SHEEP
Cullin_Nedd8 domain-containing protein.
      
 0.566
CUL7
Cullin 7; Belongs to the cullin family.
      
 0.566
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.