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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LGALS8Galectin. (338 aa)    
Predicted Functional Partners:
CALCOCO2
Calcium binding and coiled-coil domain 2.
    
 
 0.952
TAX1BP1
Tax1 binding protein 1.
   
 
 0.788
SIGLEC15
Sialic acid binding Ig like lectin 15.
    
 0.703
WIPF3
WAS/WASL interacting protein family member 3.
    
 
 0.654
ITGAM
VWFA domain-containing protein; Belongs to the integrin alpha chain family.
    
 
 0.642
MUC13
Uncharacterized protein.
    
 
 0.632
BLOC1S2
Biogenesis of lysosomal organelles complex 1 subunit 2.
      
 0.627
ITGA3
Integrin subunit alpha 3; Belongs to the integrin alpha chain family.
    
 
 0.598
ESX1
Homeobox domain-containing protein.
      
 0.584
ARMH3
Armadillo like helical domain containing 3.
      
 0.580
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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