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Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GDPD3Glycerophosphodiester phosphodiesterase domain containing 3. (320 aa)    
Predicted Functional Partners:
ENPP6
Ectonucleotide pyrophosphatase/phosphodiesterase 6.
  
 
 0.909
GDPD1
Glycerophosphodiester phosphodiesterase domain containing 1.
  
  
 
0.904
ENPP2
Ectonucleotide pyrophosphatase/phosphodiesterase 2.
  
  
 0.801
SCOC
Uncharacterized protein.
      
 0.777
PLA2G4A
Phospholipase A2.
   
 
 0.761
YPEL3
Protein yippee-like; Belongs to the yippee family.
 
 
  
 0.728
LPAR1
Lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C [...]
      
 0.722
NECAP2
NECAP endocytosis associated 2.
      
 0.710
PLA2G10
Phospholipase A(2).
   
 
 0.707
PLA2G4E
Phospholipase A2.
     
 0.687
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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