STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (118 aa)    
Predicted Functional Partners:
CD1D
Antigen-presenting glycoprotein CD1d; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells.
   
 0.995
RPA1
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
   
 0.977
RPA3
Replication protein A3.
   
 0.974
W5PJ11_SHEEP
MHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family.
   
 0.969
W5PGZ6_SHEEP
Ig-like domain-containing protein; Belongs to the MHC class I family.
   
 0.968
LOC443441
Ig-like domain-containing protein.
   
 0.965
W5PBW7_SHEEP
Ig-like domain-containing protein; Belongs to the MHC class I family.
   
 0.965
PDIA3
Protein disulfide-isomerase.
    
 0.952
LOC101107908
Ig-like domain-containing protein; Belongs to the MHC class I family.
   
 0.938
WRN
WRN RecQ like helicase.
   
 0.937
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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