Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IRF4Interferon regulatory factor 4. (453 aa)    
Predicted Functional Partners:
BCL6
BCL6 transcription repressor.
    
 0.971
BATF
Basic leucine zipper ATF-like transcription factor.
   
 0.954
PAX5
Paired box 5.
   
  
 0.918
BACH2
BTB domain and CNC homolog 2.
     
 0.913
CD4
T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.
   
 
 0.898
IL4
Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]
   
 
 0.897
PRDM1
PR/SET domain 1.
   
 0.893
AICDA
Activation induced cytidine deaminase.
      
 0.886
CXCR5
C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.876
XBP1
BZIP domain-containing protein.
    
 
 0.873
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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