Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
A1BGAlpha-1-B glycoprotein. (490 aa)    
Predicted Functional Partners:
HPX
Hemopexin.
   
 
 0.938
AFM
Afamin.
   
  
 0.870
PGLYRP2
Peptidoglycan recognition protein 2.
   
 
 0.815
LOC101102413
Uncharacterized protein; Belongs to the peptidase S1 family.
   
 0.747
AMBP
Inter-alpha-trypsin inhibitor; This inhibitory fragment, released from native ITI after limited proteolysis with trypsin, contains two homologous domains. Whereas the second domain is a strong inhibitor of trypsin, the first domain interacts weakly with PMN-granulocytic elastase and not at all with pancreatic elastase.
   
 
 0.719
AHSG
Alpha-2-HS-glycoprotein; Belongs to the fetuin family.
   
 0.705
SERPINC1
Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity).
   
 
 0.693
C1S
Complement C1s; Belongs to the peptidase S1 family.
   
 0.691
BCL2L15
BCL2 like 15.
      
 0.666
CLUL1
Clusterin; Belongs to the clusterin family.
     
 0.660
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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