SCAP protein (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SCAP

SREBF chaperone. (1082 aa)

Predicted Functional Partners:

SREBF2

0.971

SREBF1

0.967

INSIG2

0.956

INSIG1

0.955

NPC2

0.790

MYCN

0.695

MBTPS1

0.681

W5Q6U0_SHEEP

0.542

PAQR3

0.512

ACACA

0.498

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	INSIG1	ENSOARP00000000876	ENSOARP00000007077	Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.682
ACACA	SCAP	ENSOARP00000000876	ENSOARP00000004158	Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.	SREBF chaperone.	0.498
ACACA	SREBF1	ENSOARP00000000876	ENSOARP00000001571	Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.	Sterol regulatory element binding transcription factor 1.	0.864
ACACA	SREBF2	ENSOARP00000000876	ENSOARP00000020098	Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.	Sterol regulatory element binding transcription factor 2.	0.565
ACACA	W5Q6U0_SHEEP	ENSOARP00000000876	ENSOARP00000018431	Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.	Carrier domain-containing protein.	0.912
INSIG1	ACACA	ENSOARP00000007077	ENSOARP00000000876	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.	0.682
INSIG1	SCAP	ENSOARP00000007077	ENSOARP00000004158	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	SREBF chaperone.	0.955
INSIG1	SREBF1	ENSOARP00000007077	ENSOARP00000001571	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Sterol regulatory element binding transcription factor 1.	0.750
INSIG1	SREBF2	ENSOARP00000007077	ENSOARP00000020098	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Sterol regulatory element binding transcription factor 2.	0.770
INSIG1	W5Q6U0_SHEEP	ENSOARP00000007077	ENSOARP00000018431	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Carrier domain-containing protein.	0.737
INSIG2	SCAP	ENSOARP00000013097	ENSOARP00000004158	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	SREBF chaperone.	0.956
INSIG2	SREBF1	ENSOARP00000013097	ENSOARP00000001571	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Sterol regulatory element binding transcription factor 1.	0.631
INSIG2	SREBF2	ENSOARP00000013097	ENSOARP00000020098	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Sterol regulatory element binding transcription factor 2.	0.578
INSIG2	W5Q6U0_SHEEP	ENSOARP00000013097	ENSOARP00000018431	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Carrier domain-containing protein.	0.503
MBTPS1	SCAP	ENSOARP00000010899	ENSOARP00000004158	Membrane bound transcription factor peptidase, site 1.	SREBF chaperone.	0.681
MBTPS1	SREBF1	ENSOARP00000010899	ENSOARP00000001571	Membrane bound transcription factor peptidase, site 1.	Sterol regulatory element binding transcription factor 1.	0.645
MBTPS1	SREBF2	ENSOARP00000010899	ENSOARP00000020098	Membrane bound transcription factor peptidase, site 1.	Sterol regulatory element binding transcription factor 2.	0.734
MYCN	SCAP	ENSOARP00000017676	ENSOARP00000004158	MYCN proto-oncogene, bHLH transcription factor.	SREBF chaperone.	0.695
NPC2	SCAP	ENSOARP00000001118	ENSOARP00000004158	NPC intracellular cholesterol transporter 2.	SREBF chaperone.	0.790
PAQR3	SCAP	ENSOARP00000020229	ENSOARP00000004158	Progestin and adipoQ receptor family member 3.	SREBF chaperone.	0.512